It is the most common non-brain solid tumor diagnosed in children. Continued Movement Toward More Intense TreatmentĪbout 800 children are diagnosed with neuroblastoma each year in the United States. “So, while tandem transplant is the current standard, we’ll have additional information on whether alternative approaches can further improve outcomes for these children,” Dr. Other treatment approaches have also shown promise in children with high-risk neuroblastoma, she said, and NCI is supporting COG-led trials testing some of these approaches. Since that time, a tandem transplant-with the same initial (or induction) and pretransplant (or conditioning) chemotherapy regimen used in the trial-has become the standard treatment for most children in the United States with high-risk neuroblastoma, explained Nita Seibel, M.D., head of Pediatric Solid Tumor Therapeutics in NCI’s Cancer Therapy and Evaluation Program.įurther advances or treatment options are likely to emerge, Dr. The trial’s results were initially presented more than 3 years ago at the American Society of Clinical Oncology annual meeting. However, they did not have worse side effects. However, undergoing two transplants-called a tandem transplant-is more intensive, and the children who received tandem transplants had longer hospital stays, the researchers reported. Children who received two transplants separated by several weeks lived substantially longer without their cancer progressing or developing any other cancer-related problems, an outcome known as event-free survival, than children who underwent a single transplant, reported Julie Park, M.D., of Seattle Children’s Hospital, and her colleagues August 27 in JAMA. That’s according to the results of an NCI-supported clinical trial conducted by the Children’s Oncology Group (COG).Ĭhildren in the trial had high-risk neuroblastoma, meaning that their tumors had features that make the cancer particularly aggressive and difficult to treat. For many children with advanced forms of neuroblastoma, receiving two separate stem cell transplants as part of their treatment is more beneficial than receiving one.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |